Microbial Pathogenesis – Assigned Articles (April)
Note: PDF files are for use by
students for personal copies only
Variation Mechanisms/Host Resistance, ctd.
Steven J. Norris, Ph.D.
MSB 2.120
713-500-5338
23. Tuesday, April 4, 2006.
A novel variation mechanism
exemplified by a Bordetella pertussis
bacteriophage: how retro(element).
Assigned article
Liu, M., R. Deora, S. R. Doulatov, M. Gingery, F. A.
Eiserling, A. Preston, D. J. Maskell, R. W. Simons, P. A. Cotter, J. Parkhill,
and J. F. Miller. 2002. Reverse
transcriptase-mediated tropism switching in Bordetella bacteriophage. Science 295:2091-4. PDF
More recent follow-up article
McMahon, S. A., J. L. Miller, J. A. Lawton, D. E. Kerkow,
A. Hodes, M. A. Marti-Renom, S. Doulatov, E. Narayanan, A. Sali, J. F. Miller,
and P. Ghosh. 2005. The C-type lectin fold as an evolutionary solution
for massive sequence variation. Nat Struct Mol Biol 12:886-892. PDF
Note, in particular, the “Variable
proteins of other retroelements” and Discussion (highly variable proteins -
predator and prey concept) sections
24.
Thursday, April 6, 2006. Infectogenomics.
Assigned article
Sawyer, S. L., L. I. Wu, J. M. Akey, M. Emerman, and
H. S. Malik. 2006. High-frequency persistence of an impaired allele of
the retroviral defense gene TRIM5alpha in humans. Curr Biol 16:95-100. PDF
Related
review
Kellam,
P., and R. A. Weiss. 2006. Infectogenomics: insights
from the host genome into infectious diseases. Cell 124:695-697. PDF
25.
Tuesday,
April 11, 2006. Susceptibility to
tuberculosis and HLA-DQ recognition of peptides.
Delgado, J. C., A. Baena, S. Thim, and A. E.
Goldfeld. 2006. Aspartic acid homozygosity at codon 57 of HLA-DQ beta
is associated with susceptibility to pulmonary tuberculosis in
Protein Secretion
Dr. Peter
Christie
MSB 1.164
713-500-5440
26. Thursday
April 13, 2006 – Protein Secretion and Pathogenesis (Dr. Christie presenting)
Assigned
article:
Kostakioti,
M. (2005) Mechanisms of protein export across the
bacterial outer membrane J. Bacteriol. 187:4306-4315. PDF
Note: No class on Tues. April 18,
2006.
27. Thursday
April 20, 2006 – Type III secretion (Greene presenting)
Assigned
article:
Michgehl,
S. (2006) Esp-independent functional integration of
the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli
(EPEC) into host cell membranes. Cell
Microbiol. 8:625-633. PDF
Related
article:
Allen-Vercoe,
E. (2006) Enteropathogenic Escherichia coli Tir
translocation and pedestal formation requires membrane cholesterol in the
absence of bundle-forming pili. Cell
Microbiol. 8:613-624. PDF
28. Monday
April 24 – Type III effectors (Tapia presenting)
Assigned
article:
Enninga,
J. (2006) Secretion of type III effectors into host
cells in real time. Nature Methods 2:959-965.
PDF
Related
article:
Mota,
L.J. (2005) FlAsHlights on bacterial virulence proteins.
Nature Methods 2:898-899. PDF
29. Tuesday
April 25 – Type IV secretion (Kerr presenting)
Assigned
article:
Bagnoli,
F. 2005. Helicobacter pylori CagA
induces a transition from polarized to invasive phenotypes in MDCK cells. Proc. Natl. Acad. Sci. USA 102:16339-16344 (Also see supplementary
information) PDF
Related
article:
Backert,
S. (2006) Bacterial type IV secretion systems and their
effectors in bacterial pathogenesis
Curr. Opin, Microbiol. 9:207-217.
PDF
30. Thursday
April 27 – Type VI secretion (Pflughoeft presenting)
Assigned
article:
Balsalobre,
C. (2005) Release of the type I
secreted a-hemolysin via outer membrane vesicles from Escherichia coli. Mol. Microbiol. 59:99-112.
PDF
Related
article:
Kuehn, M. (2006) Bacterial outer membrane vesicles and
the host – pathogen interaction. Genes
Dev. 19:2645-2655. PDF